Hydroxyurea Induced Perimalleolar Ulcers

Hydroxyurea Induced Perimalleolar Ulcers

Hydroxyurea (HU) is an antineoplastic drug commonly used to treat chronic myeloproliferative disorders. Common dermatological side effects include hyperpigmentation, scaling, erythema, alopecia, desquamation of face and hands. Leg ulceration following HU therapy is less common and very few cases have been reported so far. Objective of this paper is to increase the awareness of hydroxyurea induc...

Hydroxyurea-induced ulcers on the leg.

Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix.

BACKGROUND The development of painful leg ulcers in the ankle area is a rare and only partially described complication in patients receiving high-dose, long-term hydroxyurea treatment for myeloproliferative diseases. Several reports have described treatments for chronic wound management with this type of lesion. OBSERVATIONS We describe 2 patients who were diagnosed as having hydroxyurea-indu...

Hydroxyurea and colonic ulcers: a case report

BACKGROUND Hydroxyurea at a relatively low dose is frequently prescribed to induce hemoglobin F production in patients with sickle cell and β-thalassemia diseases because of its good efficacy and safety profiles. However, a potentially fatal gastrointestinal ulceration was recently found and herein reported. CASE PRESENTATION A thirty-seven-year-old man with transfusion dependent hemoglobin E...

Hydroxyurea Induced Longitudinal Melanonychia: A Picture Presentation

This is a picture presentation of myeloproliferative disorder developing to longitudinal melanonychia as a side effect of hydroxyurea. Keywords: Melanonychia, hydroxyurea, side effect.